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CHROMOSOMAL ABERRATIONS IN PERIPHERAL LYMPHOCYTES OF STUDENTS EXPOSED TO AIR POLLUTANTS
Citation:
Scott, C. AND J. Burkart. CHROMOSOMAL ABERRATIONS IN PERIPHERAL LYMPHOCYTES OF STUDENTS EXPOSED TO AIR POLLUTANTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-78/054 (NTIS PB285594), 1978.
Description:
The research program was initiated with the overall objective of determining whether or not photochemical air pollutants have the potential to cause chromosome breakage in environmentally exposed individuals; if so, could chromosomal changes be used as a biological indicator of exposure to certain environmental conditions in the Los Angeles, CA basin. 256 incoming Freshmen students at the University of So. California were selected, matched, and grouped by home address into in-basin males and females, and out-of-basin males and females. Blood samples were collected from them at the following sampling time: October 1974, February, May and October 1975, and May 1976. All slides were analyzed in a double blind fashion, with 100 cells per student per sampling time being scored. All 100 cells were analyzed for chromosome and chromatid aberrations; however, only 25 cells of this 100 were counted for aneuploidy. Overall, in-basin males had significantly more abnormal cells, breaks, and gaps than out-of-basin males. Females showed the same trends but only for abnormal cells were the results borderline statistically significant. (Portions of this document are not fully legible)