You are here:
HEPATIC AND RENAL ASSESSMENT OF ACUTE EXPOSURE TO INHALED EPICHLOROHYDRIN: TOXICOLOGICAL EVALUATION AND EXPOSURE MODELING
Citation:
Robinson, B., J. Andrews, J. Allis, A. McDonald, J. Simmons, D. Guinnup, T. Mohin, AND J. Seely. HEPATIC AND RENAL ASSESSMENT OF ACUTE EXPOSURE TO INHALED EPICHLOROHYDRIN: TOXICOLOGICAL EVALUATION AND EXPOSURE MODELING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/348, 1995.
Description:
To determine the hepatic and enal effects of acute exposure to inhaled epichlorohydrin (ECH), male F-344 rats were exposed either to 0 or to 100 ppm ECH by inhalation for 4 hours. epatic and renal toxicity-were assessed at the termination of exposure and on the first, second and third days post-exposure. xposure to inhaled ECH caused no histopathological evidence of hepatic or renal toxicity and had no effect on serum indicators of hepatic or renal toxicity, liver weight or hepatic cytochrome P-450 and glutathione concentrations. xposure to inhaled ECH resulted in a readily reversible increase in absolute and relative kidney weight on the first day postexposure in young adult (65/73 day old) rats but not in mature (96 day old) rats. hese observations provide consistent evidence that acute exposure to 100 ppm ECH did not produce overt hepatic or renal toxicity. mbient impact assessment modeling (AIAM), a methodology for estimation of exposure over short time periods and comparison of these predicted ambient concentration levels to short-term toxicological threshold values, was conducted from three typical sources of ECH pollution. he results of these analyses illustrated the interdependence of toxicological evaluation and exposure modeling in short-term noncancer risk assessment and demonstrated the usefulness of AIAM in prioritizing chemicals from additional toxicological evaluation.