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PULMONARY FUNCTION, AIRWAY RESPONSIVENSS, AND RESPIRATORY SYMPTOMS IN ASTHMATICS FOLLOWING EXERCISE IN NO2
Citation:
Roger, J., D. Horstman, W. McDonnel, H. Kehrl, P. Ives, E. Seal, AND R. Chapman. PULMONARY FUNCTION, AIRWAY RESPONSIVENSS, AND RESPIRATORY SYMPTOMS IN ASTHMATICS FOLLOWING EXERCISE IN NO2. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/078 (NTIS PB90245481), 1990.
Description:
Asthmatics performed three l0-min moderate exercises while exposed to 0.00 and 0.30 NO2. ollowing the initial exercise, FEV1 decreased to a greater extent (p<0.05) in NO2 than in air (7%). After the second and third exercises, decreases in FEV1 and FVC and increases in SRaw were significantly greater in NO2 than in air. hese results prompted the conduct of a more comprehensive concentration-response study. sthmatics were exposed to 0.0, 0.15, 0.30, and 0.60 ppm NO2; again 10-min moderate exercises were included. hen compared to air exposure, there were no pulmonary responses after any exercise in any concentration of NO2. irway responsiveness to nethacholine after NO2 exposure was also not different from that after air exposure. he findings of no effects this larger concentration-response study do not support the findings of preliminary single-concentration study. ossible explanations are differences in subject sampling, variability in subjects' responses, or other factors such as seasonal variation in response.
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PULMONARY FUNCTION, AIRWAY RESPONSIVENSS, AND RESPIRATORY SYMPTOMS IN ASTHMATICS FOLLOWING EXERCISE IN NO2