You are here:
REGIONAL DEPOSITION OF INHALED REACTIVE GASES
Citation:
Miller, F., J. Overton, AND R. Graham. REGIONAL DEPOSITION OF INHALED REACTIVE GASES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-87/078 (NTIS PB87166989), 1987.
Description:
A critical concept in inhalation toxicology involves the determination of dose as the first component for providing a perspective to judge the applicability of various toxicological results to human exposure conditions. Available experimental data for reactive gases were reviewed, and basic concepts in the formulation of mathematical dosimetry models were discussed. The complexity of factors influencing dose was illustrated as related to rate constant sensitivity, thickness of the protective layer of the lungs, the choice of anatomical model, ventilatory parameters, and path distance. Results obtained thus far illustrate the feasibility of making interspecies dosimetric comparisons as an integral step in evaluating the toxicity of inhaled reactive gases, assisting in experimental design, and providing sensitivity studies to determine parameters and processes needing additional research.