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ALLERGIC RESPONSE TO PLATINUM AND PALLADIUM COMPLEXES DETERMINATION OF NO-EFFECT LEVEL
Citation:
Taubler, J. ALLERGIC RESPONSE TO PLATINUM AND PALLADIUM COMPLEXES DETERMINATION OF NO-EFFECT LEVEL. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-77/039 (NTIS PB271659), 1977.
Description:
Rabbits, guinea pigs and mice were subcutaneously injected with PtSO4 (with and without NH4Cl) and PdSO4 (with and without NH4Cl) in an attempt to sensitize the animals to platinum or palladium. No allergic induction was found. No allergic induction to platinum or palladium was found in rabbits, guinea pigs or mice when these animals were injected intravenously with platinum or palladium. Dermal contact with platinum was also tested on rabbits and guinea pigs but failed to induce an allergic state. Platinum and palladium levels in the sera, urine and spleens of the animals, as monitored by AAS, were not significant. Rabbits, guinea pigs and mice were intravenously or subcutaneously injected with a platinum-egg albumin complex or a palladium-egg albumin complex. Skin tests or footpad tests were performed 10-14 days after the last intravenous or subcutaneous injection. Only guinea pigs injected subcutaneously with palladium-egg albumin complex developed a hypersensitivity of the delayed type. A delayed type allergy was induced in guinea pigs subcutaneously injected with palladium complexed to egg albumin.