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IMMUNOTOXICITY - BRIDGING THE GAP BETWEEN ANIMAL RESEARCH AND HUMAN HEALTH EFFECTS
Citation:
Selgrade, M., K. Cooper, R. Devlin, H. Loveren, R. Giagini, AND M. Luster. IMMUNOTOXICITY - BRIDGING THE GAP BETWEEN ANIMAL RESEARCH AND HUMAN HEALTH EFFECTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/127, 1995.
Description:
There is amply evidence that a number od xenobiotics suppress various components of the immune system and enhance susceptibility to disease when tested in laboratory animals. There is much less data of effects of xenobiotics on human immune responses. The challenge is to interpret animal data in terms of human health effects. Speakers will present human data on immunosuppressive effects caused by exposure to O3, UV radiation, and therapeutic drugs, e.g., cyclosporin A, and will discuss the relationship between human and animal responses to these agents (for which controlled human exposures are possible) as well as implications for enhanced susceptibility to infectious and neoplastic disease. Additional presentations will discuss an alternate approach to bridging the animal/human gap in cases where controlled human exposures are not possible, and studies designed to assess the effects of occupational exposures on the immune response and difficulties associated with such studies. For immunotoxicity the questions in risk assessment still seems to be: What's the hazard? and What's the evidence that humans are at risk? This symposium will address those issues.