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KINETICS STUDY OF CHLORIDE IN RAT
Citation:
Suh, D. AND M. Abdel-Rahman. KINETICS STUDY OF CHLORIDE IN RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/197 (NTIS PB84178953), 1983.
Description:
The kinetics of chloride were studied in Sprague-Dawley rats following the oral administration of Na36Cl. The half-life for (36)Cl(-1) absorption from plasma was 19.2 hr corresponding to a rate constant of 0.0361 hr, while the half-life for (36)Cl(-1) elimination from plasma was 51.9 hr corresponding to a rate constant 0.0134 hr. At 120 hr, radioactivity was highest in plasma followed by kidney, lung, stomach and spleen, whereas the lowest activity was observed in fat. Plasma and packed cells contained almost the same concentration of (36)Cl(-1). Plasma protein binding of chloride was significantly higher than liver protein binding. Subcellular distribution in liver fractions revealed that most of the (36)Cl(-1) was located in the cytosolic fraction. The excretion of chloride occurred primarily by the kidney. (Copyright (c) 1983 by Hemisphere Publishing Corporation.)