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LOCALIZATION OF THE MOUSE THYMIDINE KINASE GENE TO THE DISTAL PORTION OF CHROMOSOME 11
Citation:
Hozier, J., J. Sawyer, N. DeVassal, M. Applegate, D. Clive, AND M. Moore. LOCALIZATION OF THE MOUSE THYMIDINE KINASE GENE TO THE DISTAL PORTION OF CHROMOSOME 11. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/177 (NTIS PB91233395), 1991.
Description:
We report the regional mapping of the thymidine kinase (tk-1) gene in the mouse using two complementary analyses: 1) investigation of chromosome aberrations associated with tx-1 gene inactivation in the L5178Y TX+/-3.7.2c cell line and (2) in situ molecular hybridization of a cloned tk-1 cDNA probe to mitotic chromosomes of this cell line. he consensus location for both analyses is 11B2-C1. omparison of the mouse tk-1 gene localization with evidence that the homologous TX-I gene is located distally on the large arm of chromosome 17 appears to extend the region of homology between MMU11 and HSA17 to include the distal segments of both.
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LOCALIZATION OF THE MOUSE THYMIDINE KINASE GENE TO THE DISTAL PORTION OF CHROMOSOME 11