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COMPARISON OF MUTAGENIC ACTIVITIES OF SEVERAL PEROXYACL NITRATES
Citation:
Kleindiesnt, T., P. Shepson, D. Smith, E. Hudgens, C. Nero, L. Cupitt, J. Bufalini, AND L. Claxton. COMPARISON OF MUTAGENIC ACTIVITIES OF SEVERAL PEROXYACL NITRATES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/535 (NTIS PB91183251), 1990.
Description:
Salmonella typhimurium, strain TA100 was exposed to a series of peroxyacyl nitrates including peroxyacetyl nitrate (PAN), peroxypropionyl nitrate (PPN), peroxybutyryl nitrate (PBN), peroxybenzoyl nitrate (PBzN), and chloroperoxyacetyl nitrate (CPAN). as-phase concentrations for the individual exposures were in the high part per billion by volume ppbv range. he dose was etermined from the deposition rate and measured from the net decrease of the test compound in the exposure chamber and the exposure time. he mutagenic activity for each compound determined rom the dose-response relationship gave values ranging from 250(PBN) to 6,500 (PBzN) revertants/umol. he mutagenic activity or CPAN could not be determined, due to an interference from chloroacetaldehyde. he difficulties of quantifying the actual gas-phase chemical dose the bacterial are exposed to in this variant of the Ames test are delineated.
