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BUPROPION, D-AMPHETAMINE, AND AMITRIPTYLINE-INDUCED CONDITIONED TASTE AVERSION IN RATS: DOSE EFFECTS
Citation:
Miller, D. AND L. Miller. BUPROPION, D-AMPHETAMINE, AND AMITRIPTYLINE-INDUCED CONDITIONED TASTE AVERSION IN RATS: DOSE EFFECTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/128 (NTIS PB84144294), 1983.
Description:
Nine groups of rats (n+6 per group) were adapted to a daily one-half hour period of water availability. When intake had stabilized, they were allowed access to a 0.1% (w/v) solution of saccharin, and immediately afterward were given IP injections of isotonic saline; bupropion HCl (10.0, 20.0, or 40.0 mg/kg); d-amphetamine-sulfate (0.5, 1.0, 2.0 mg/kg); or amitriptyline HCl (5.0, 10.0, or 20.0 mg/kg); in a volume of 1 ml. The lowest dose of each compound was chosen to be equipotent in screening tests used to identify potential antidepressants. Following 2 days of access to water alone, all groups were given a choice between water and saccharin for 3 consecutive days. All compounds induced taste aversions in a dose-related manner, but amitriptyline induced greater and longer-lasting aversions than either bupropion or d-amphetamine which were equipotent over the dose range studied.