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GENOTOXICITY IN MOUSE LYMPHOMA CELLS OF CHEMICAL CAPABLE OF MICHAEL ADDITION
Citation:
Dearfield, K.L., K. Harrington-Brock, C.L. Doerr, J. Rabinowitz, AND M. Moore. GENOTOXICITY IN MOUSE LYMPHOMA CELLS OF CHEMICAL CAPABLE OF MICHAEL ADDITION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/324 (NTIS PB92120484), 1991.
Description:
Chemical agents that react via the Michael addition reaction have important industrial and consumer applications. ne of them, acrylamide, is used largely in the production of polymers as a flocculent in sewage and wastewater treatment, for coagulant treatment of potable water and to improve the quality of paper products (Davis et al., 1976). onomeric acrylamide is used to produce grouts and soil stabi1izers for construction (Davis et al., 1976). crylate and methacrylate esters are used to produce polymers and resins in surface coatings, emulsion polymers and specialty plastics (IARC, 1979). inyl sulfone moieties are used in fiber-reactive dyes (MacGregor et al., 1980). hemical reactivity via Michael addition is essential for many of the uses for which these compounds are important. he same properties that make these chemicals industrially important also make them potential agents for Michael addition to biopolymers and biomolecular targets. t is also clear that the potential for environmental and human exposure may be of major concern. s such, the U.S Environmental Protection Agency's (USEPA's) Office of Toxic Substances (OTS) has been evaluating the potential health hazards of these compounds; in particular, acrylamide (Dearfield et al., 1988) and the acrylate/methacrylate esters (USEPA, 1987).