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EVALUATION OF THE EFFECTS OF METHANOL DURING EARLY PREGNANCY IN THE RAT
Citation:
Cummings, A. EVALUATION OF THE EFFECTS OF METHANOL DURING EARLY PREGNANCY IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/377 (NTIS PB93231850), 1993.
Description:
Recent attention to methanol (MeOH) as a potential alternative fuel prompted an evaluation of the chemical's effects during very early pregnancy. ats were dosed by gavage during Days 1-8 of pregnancy at 0, 1.6, 2.4 or 3.2 g MeOH/kg/day. roups of animals were killed on Days 9, 11 or 20 of pregnancy, and maternal, embryonic, or fetal parameters were assessed, depending on the stage of pregnancy. he decidual cell response (DCR) technique was also applied to rats treated with MEOH during pseudopregnancy. eductions in pregnant uterine and implantation site weights seen on Day 9 are the result of MEOH impedance of normal decidualization, as demonstrated by effects on the DCR. n increase in the extravasation of blood at implantation sites.seen on Day 9 was not reflected as increased resorptions by Day 20. o effect on Day 11 or Day 20 embryo-fetal survival or development was observed.