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BITERTANOL, A TRIAZOLE FUNGICIDE, INCREASES OPERANT RESPONDING BUT NOT MOTOR ACTIVITY
Citation:
Allen, A. AND R. MacPhail. BITERTANOL, A TRIAZOLE FUNGICIDE, INCREASES OPERANT RESPONDING BUT NOT MOTOR ACTIVITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/400 (NTIS PB93236370), 1993.
Description:
Several recent reports indicate that triadimefon, a triazole fungicide, has effects on behavior that are similar to those of psychomotor stimulants. or example, both d-amphetamine and triadimefon increase rates and disrupt patterns of responding maintained under FI schedules of reinforcement. he present study was designed to determine whether the stimulant-like effects of triadimefon on FI performance extended to another triazole fungicide, bitertanol. ffects of bitertanol (10-300 mg/kg) were determined in four rats performing under a multiple FI 1-minute FI 5-minute schedule of reinforcement. esponse rates were increased and then decreased to control levels or below by increasing dosages of bitertanol. esponse rate increases were greater in the FI 5-minute component. itertanol also cosage-dependently disrupted the temporal pattern of responding in both components. isruptions were small in the FI 1-minute component but large in the FI 5-minute component. hese findings indicate that bitertanol produces effects on FI performance similar to those of triadimefon.