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EARLY CEREBELLAR LESIONS IMPAIR EYEBLINK CONDITIONING IN DEVELOPING RATS: DIFFERENTIAL EFFECTS OF UNILATERAL LESIONS ON POSTNATAL DAY 10 OR 20
Citation:
Freeman, Jr., J., C. Carter, AND M. Stanton. EARLY CEREBELLAR LESIONS IMPAIR EYEBLINK CONDITIONING IN DEVELOPING RATS: DIFFERENTIAL EFFECTS OF UNILATERAL LESIONS ON POSTNATAL DAY 10 OR 20. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-96/059, 1995.
Description:
This study attempted to evaluate the role of the cerebellum in the acquisition of eyeblink conditioning in developing rats, Experiment 1 demonstrated that the ipsilateral cerebellar hemispheric cortex and deep nuclei are essential for the acquisition of eyeblink conditioning in developing rats. t also showed that cerebellar lesions given on Postnatal Day 10 (PND10) produced deficits in eyeblink conditioning when given to either hemisphere. or both hemispheres, lesions that were restricted to the cerebellar cortex produced less severe deficits than lesions that included the deep nuclei. xperiment 2 showed that the age at which the cerebellar lesions occurred determined whether damage to the contralateral cerebellar hemisphere impaired conditioning. esions of either the ipsilateral or contralateral hemisphere given on PND10 disrupted eyeblink conditioning. n contrast, when the lesions were given on PND20, ipsilateral lesions abolished conditioning, while contralateral lesions had no effect. hese results suggest that the development of eyeblink conditioning in rats depends upon the maturation of the cerebellar hemisphere that is ipsilateral to the trained eye.