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COLOR YES; CANCER NO
Citation:
Freeman, H., M. Esancy, J. Esancy, AND L. Claxton. COLOR YES; CANCER NO. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/244 (NTIS PB92110477), 1991.
Description:
Dyes based on known carcinogens such as benzidine and beta naphthylamine can no longer be manufactured in the United States. n addition, numerous colorants have been banned from use by the food and cosmetic industries. hese limitations have led to the examination of structure-activity relationships that could help in the development of suitable nongenotoxic dyes and dye precursors. ur goal was to demonstrate how nonmutagenic dyes could be developed by identifying nongenotoxic dyestuff intermediates. ur working hypothesis stated that an azo dye would be nonmutagenic if both the synthetic precursors and reductive cleavage products of the dye were nonmutagenic themselves. y examining a related series of compounds, this work was able to demonstrate the effect of adding specific substructural components to parent compounds used in the synthesis of dyes. his paper provides an overview of these structure-activity studies.
