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RELATIONSHIPS BETWEEN BIOMARKERS OF EXPOSURE AND NEUROLOGICAL EFFECTS IN A GROUP OF WORKERS EXPOSED TO ACRYLAMIDE
Citation:
Calleman, C., Y. Wu, e. Bergmark, H. Deng, K. Crofton, S. Zhang, T. Fennell, G. Tian, C. Nauman, AND L. Costa. RELATIONSHIPS BETWEEN BIOMARKERS OF EXPOSURE AND NEUROLOGICAL EFFECTS IN A GROUP OF WORKERS EXPOSED TO ACRYLAMIDE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/122, 1994.
Description:
A study was performed among 41 workers heavily exposed to a mixture of acrylamide and acrylonitrile in Henan province of China. The workers underwent a complete medical and neurological examination and gave blood and urine for the determination of several biomarkers of exposure. Statistically increased frequencies were found among the exposed workers of signs and symptoms indicating neurological disorders as compared to a group of controls from the same city. A Neurotoxicity Index specific for acrylamide-induced peripheral neuropathy was designed based on signs, symptoms and quantifiable indicators of neurotoxicity, such as vibration thresholds and electroneuromyography measurements. This Neurotoxicity Index, which adequately predicted the clinical diagnosis of peripheral neuropathy, was significantly correlated with the levels of mercapturic acids in 24 hr urine, hemoglobin adducts of acrylamide, estimated life-time in vivo dose of acrylamide, employment time and vibration sensitivity. The Neurotoxicity Index was also correlated with hemoglobin adducts of acrylonitrile, which could at least partially be explained by a correlation between acrylamide and acrylonitrile exposure in this