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HEPATOTOXIC INTERACTIONS OF ETHANOL WITH ALLYL ALCOHOL OR CARBON TETRACHLORIDE IN RATS
Citation:
Berman, E., D. House, J. Allis, AND J. Simmons. HEPATOTOXIC INTERACTIONS OF ETHANOL WITH ALLYL ALCOHOL OR CARBON TETRACHLORIDE IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/443 (NTIS PB93141422), 1992.
Description:
To assess interactive toxicity following subacute, concurrent chemical exposure, male Fischer-344 rats, approximately 70 days of age, were given ethanol at 0, 0.'05, 0.1, 0.2, or 0.5 ml/kg in corn oil daily by gavage for 14 days ([TON group), or the same levels of ethanol with 21 mg of allyl alcohol/kg (ALAC group), or the same levels of ethanol with 20 mg of carbon tetrachloride/kg (CCL4 group). epatic response was assessed 24 hr after the last dose. nteractions were evaluated by comparing the [TON group with either the ALAC group or the CCL4 group using multivariate analysis of variance procedures. o statistically significant interaction was seen between the [TON group and the ALAC group at the dosages used. lthough the hypothesis of interaction could not be rejected for the combination of ethanol and carbon tetrachloride, a small interactive effect on weight gain from Day-0 to termination was apparent. xposure to ethanol alone resulted in a concentration-dependent decrease in absolute and relative weight but caused no histopathological evidence of hepatic damage and had no effect on hepatic cytochrome P450 and glutathione levels or serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALK). xposure to allyl alcohol resulted in significant increases, relative to ethanol alone, in absolute and relative liver weight, serum levels of ALT, AST and ALK and centrilobular.