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SYNERGISTIC AND ANTAGONISTIC EFFECTS ON GENOTOXICITY OF CHEMICALS COMMONLY FOUND IN HAZARDOUS WASTE SITES
Citation:
Ma, T., S. Sandhu, Y. Peng, T. Chen, AND T. Kim. SYNERGISTIC AND ANTAGONISTIC EFFECTS ON GENOTOXICITY OF CHEMICALS COMMONLY FOUND IN HAZARDOUS WASTE SITES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/426 (NTIS PB93141257), 1992.
Description:
Synergistic and antagonistic effects on genotoxicity of mixtures of four chemicals; i.e., lead tetraacetate (LTA), arsenic trioxide (ATO), dieldrin (DED), and tetrachloroethylene (TCE), were evaluated by the Tradescantia-Micronucleus (Trad-MCN) assay. he concentration of stock solution of these chemicals was around the minimum effective dose (MED) or below the MED for these cheimcals as reported by Sandhu et al. (1989). reatments were applied to plant cuttings by absorption of the mixed solutions through the stems of the plant for 30 h followed by fixation of the flower buds in aceto-alcohol (3:1 ratio) without a recovery period. esults indicated that the mixture of LTA/ATO exhibited antagonistic effects. hese data indicate that for evaluating biological hazards at chemical waste sites, it is prudent to evaluate the genotoxicity of complex chemical mixtures as these exist in nature because the biological effects, based on evaluating individual chemicals, may not be true predictors of the interactive effects of the pollutants.