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IN VIVO AND IN VITRO DERMAL PENETRATION AND PHARMACOKINETICS OF 2,4,5,2',4'5'-HEXACHLOROBIPHENYL IN YOUNG AND ADULT RATS
Citation:
Fisher, H., P. Shah, M. Sumler, AND L. Hall. IN VIVO AND IN VITRO DERMAL PENETRATION AND PHARMACOKINETICS OF 2,4,5,2',4'5'-HEXACHLOROBIPHENYL IN YOUNG AND ADULT RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/370 (NTIS PB90215898), 1989.
Description:
Penetration of l4C-2,4,5,2'4'5'-hexachlorobiphenyl (PCB) through skin of young (33 days) and adult (82 days) female Fischer 344 rats was determined in vivo and by two in vitro methods. n vivo dermal penetration at 120 hours was 45% in young and 43% in adults. t 72 hours in vivo dermal penetration was 35% in young and 26% in adults compared to 1.3% for young and 1.4% for adult as measured with a continuous flow in vitro system and 2.5% for young and 1.2% for adults as measured with a static in vitro system. ost of the absorbed PCB remained in the body as only 4.9% and 2.6% of that absorbed was excreted by young and adult rats respectively by 120 hours. he excretion of PCB into feces was approximately six times higher than into urine. hysiological pharmacokinetic model was fit to the organ and tissue distribution data. arameters in the model determined from dermal dosing of female Fischer-344 rats were in reasonable agreement with those obtained from i.v. dosing of adult male Sprague Dawley rats. ifferences in the model parameters between young and adult rats were found. he rate constant for dermal penetration was 0.83 x lO-4 min-1 for adults and 0.96 x lO-4 min-1 for young. he delay or log time parameter for dermal penetration was 4.4 hr in adults and 1.1 hr in young.