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UTILITY OF ACTIVITY AND OBSERVATIONAL DATA FOR NEUROTOXICITY SCREENING
Citation:
Moser, V. UTILITY OF ACTIVITY AND OBSERVATIONAL DATA FOR NEUROTOXICITY SCREENING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-92/194 (NTIS PB92232826).
Description:
Observational and activity tests provide neurobehavioral data critical for assessing a chemical's effects on the nervous system. he measures are sensitive, relatively specific, and provide information about the effects of the chemical in specified functional domains. These measures are also valuable additions to mechanistic studies, although not specifically desired for this purpose. urthermore, they are sufficiently sensitive that conservative exposure standards could be determined in the absence of additional neurotoxicity data. There are numerous advantages to including these tests in acute, subchronic, or chronic studies. he measures arc quite reliable over time, and given the additional benefits of collecting neurobehavioral data, there is food reason to include these assessments in standard toxicity tests.
