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SYNAPTONEMAL COMPLEX DAMAGE AS A MEASURE OF GENOTOXICITY AT MEIOSIS
Citation:
Allen, J.W., P. Poorman, L. Backer, J. Gibson, AND B. Westbrook-Collins. SYNAPTONEMAL COMPLEX DAMAGE AS A MEASURE OF GENOTOXICITY AT MEIOSIS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-88/136 (NTIS PB88223789), 1988.
Description:
Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.