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EFFECTS OF MANGANESE, CALCIUM, MAGNESIUM, AND ZINC ON NICKEL-INDUCED SUPPRESSION OF MURINE NATURAL KILLER CELL ACTIVITY
Citation:
Smialowicz, R., R.R. Rogers, M. Riddle, R. Luebke, AND L. Fogelson. EFFECTS OF MANGANESE, CALCIUM, MAGNESIUM, AND ZINC ON NICKEL-INDUCED SUPPRESSION OF MURINE NATURAL KILLER CELL ACTIVITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/031 (NTIS PB87198404), 1987.
Description:
The effects that divalent metals have on nickel-induced suppression of natural killer (NK) cell activity were studied in mice. Male CBA/J mice were given a single intramuscular injection of nickel chloride (4.5-36 micrograms NiCl2/g), manganese chloride (20-80 micrograms MnCl2/g), magnesium acetate (50-200 micrograms MgOAc/g), zinc acetate (208 micrograms AnOAc/g) or calcium acetate (12.5-50 micrograms CaOAc/g), and splenic NK cell activity was assessed 24 hours later using a (51)Cr release assay. The data indicate that both the divalent metal and the timing of its injection relative to Ni injection are critical for altering Ni-induced suppression of NK cell activity. (Copyright (c) 1987 by Hemisphere Publishing Corporation.)