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EFFECT OF METHYL LINOLEATE HYDROPEROXIDE (MLHP), A POSSIBLE TOXIC INTERMEDIATE OF OZONE, ON HUMAN NORMAL AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G-6-PD) DEFICIENT ERYTHROCYTES
Citation:
Williams, P., E. Calabrese, AND G. Moore. EFFECT OF METHYL LINOLEATE HYDROPEROXIDE (MLHP), A POSSIBLE TOXIC INTERMEDIATE OF OZONE, ON HUMAN NORMAL AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G-6-PD) DEFICIENT ERYTHROCYTES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-83/277 (NTIS PB85177855), 1983.
Description:
Erythrocytes of both normal and G-6-PD deficient humans responded in a dose-dependent manner to the oxidant stress of MLHP as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels and decreases in reduced glutahione (GSH). The G-6-PD deficient erythrocytes displayed a markedly enhanced sensitivity to MLPH induced decreases in G-6-PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels. (Copyright (c) 1983 by Marcel Dekker, Inc.)