You are here:
BRAIN CHOLINESTERASE ACTIVITY OF BOBWHITE ACUTELY EXPOSED TO CHLORPYRIFOS
Citation:
Cairns, M., C. Maguire, B. Williams, AND J. Bennett. BRAIN CHOLINESTERASE ACTIVITY OF BOBWHITE ACUTELY EXPOSED TO CHLORPYRIFOS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/108 (NTIS PB91207019), 1991.
Description:
Northern bobwhite, Colinus virginianus, were orally dosed with the organophosphorus insecticide chlorpyrifos to examine effects on brain cholinesterase (AChE) activity. wo-week-old quail were acutely exposed and euthanized at selected times following gavage-dosing, ranging from 1 to 120 h later. he AChE activity was determined in treated birds and compared to concurrently tested control (corn oil) birds. t was found that a lag time of 2 to 4 h following dose exposure was necessary to detect significant AChE depression caused by chlorpyrifos. he lowest dose that produced ChE to detect significant ChE depression in these tests was between 30 and 50 mg chlorpyrifos/kg body weight, with some mortality occurring at the high end of that range. epression typically persisted for at least 24 h.