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CONCENTRATION-TIME MODELS FOR THE EFFECTS OF OZONE ON BRONCHOALVEOLAR LAVAGE FLUID PROTEIN FROM RATS AND GUINEA PIGS
Citation:
Highfill, J., G. Hatch, D. Costa, R. Slade, K. Crissman, J. Norwood, AND R. Devlin. CONCENTRATION-TIME MODELS FOR THE EFFECTS OF OZONE ON BRONCHOALVEOLAR LAVAGE FLUID PROTEIN FROM RATS AND GUINEA PIGS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/073 (NTIS PB92150879), 1992.
Description:
Questions of the adequacy of existing ozone (O3) standards prompted an examination of relationships between concentration (C) and exposure time (T) and the impact of changes in the C x T product on toxic responses. sing protein concentration of bronchoalveolar lavage fluid (BALP) as an index of O3-induced lung damage, models were developed from a matrix of C (0.0, 0.1, 0.2, 0.4, and 0.8 ppm) and T (2, 4, and 8 hrs) values in rats and guinea pigs. qual C x T products with different levels of C and T were incorporated into the protocol. wo least squares response surface models were given and evaluated for rats and guinea pigs. or equal C x T products the results showed similar BALP responses at low C x T products but showed inconsistent differences in BALP for high C x T products. alculations from the data and the response surface models showed (1) the models were consistent with reported experiments from our laboratory, (2) the exercising humans were more sensitive to O3 exposure than were either the rats and guinea pigs as measured by changes in BALP, and (3) one model, the exponential surface model, satisfied Haber's Law.