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EFFECTS OF CHEMICALLY-INDUCED MATERNAL TOXICITY ON PRENATAL DEVELOPMENT IN THE RAT
Citation:
Chernoff, N., R. Setzer, D. Miller, J. Rogers, AND M. Rosen. EFFECTS OF CHEMICALLY-INDUCED MATERNAL TOXICITY ON PRENATAL DEVELOPMENT IN THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/074 (NTIS PB92150887), 1990.
Description:
The hypothesis that chemically-induced overt maternal toxicity induces a characteristic syndrome of adverse developmental effects in the rat was investigated. regnant animals (Sprague-Dawley strain) were dosed by oral gavage with one of a series of compounds on days 6 through 15 of gestation. hese chemicals were diquat (DIQ), ethylene-bis-isothiocyanate EBIS), toxaphene (TOX), styrene (STY), 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichloro-phenol (2,4,5-Tr), triphenyl tin hydroxide (TPTH), and cacodylic acid (CAC). he compounds were chosen because they exhibited little or no developmental toxicity in previous studies. osage levels producing maternal weight loss and/or lethality were determined from preliminary toxicity studies. ignificant maternal weight reductions were noted during the course of treatment with all compounds except CAC and 2,4,5-Tr. aternal lethality was produced by EBIS, TOX, 2.4,-D, and 2,4,5-Tr. he main treatment-related developmental toxicity noted in litters at term consisted of increased lethality (EBIS, TPTH) and decreased fetal weight (EBIS and CAC). reatment-related anomalies were seen in litters treated with 2,4-D and TOX (supernumerary ribs), and [EBIS and STY (enlarged renal pelvis). o significant developmental effects were produced with DIQ, or 2,4,5-Tr. his study indicates that overt maternal toxicity as defined by weight loss or mortality Is not associated with a defined syndrome of adverse developmental effects in the rat.