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FATE OF ADRIAMYCIN-INDUCED DILATED RENAL PELVIS IN THE FETAL RAT: FUNCTIONAL AND MORPHOLOGICAL EFFECTS IN THE OFFSPRING
Citation:
Kavlock, R., B. Rehnberg, AND E. Rogers. FATE OF ADRIAMYCIN-INDUCED DILATED RENAL PELVIS IN THE FETAL RAT: FUNCTIONAL AND MORPHOLOGICAL EFFECTS IN THE OFFSPRING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/243 (NTIS PB88177043), 1987.
Description:
Previously the authors reported that gestational exposure to Adriamycin, an anthracycline antibiotic used in the treatment of neoplasms, reduced renal function in the neonatal rat, and the authors suggested that alterations in the development of the renal papilla might be responsible for the disfunction. In the study the authors exposed groups of Sprague-Dawley rats to 0, 1.0, 1.25 or 1.5 mg/kg of adriamycin on gestation days 10-12, a period previously shown to be effective in altering postnatal renal function with this compound. Offspring were evaluated at several developmental periods in order to: (1) precisely define the morphological status of the urogenital system in adriamycin-treated offspring; (2) replicate the finding of a decreased renal concentrating ability in the neonates; (3) determine the transience/permanence of any morphological effect; and (4) correlate any permanent alterations in urogenital morphology with the indicator of neonatal functional competence. Maternal adriamycin treatment induced alterations in the development of the renal papilla that persisted well into the postnatal life of the offspring.