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FUNCTIONAL ASPECTS OF DEVELOPMENTAL TOXICITY OF POLYHALOGENATED AROMATIC HYDROCARBONS IN EXPERIMENTAL ANIMALS AND HUMAN INFANTS
Citation:
Brouwer, A., U. Ahlborg, M. Berg, L. Birnbaum, AND e. al. FUNCTIONAL ASPECTS OF DEVELOPMENTAL TOXICITY OF POLYHALOGENATED AROMATIC HYDROCARBONS IN EXPERIMENTAL ANIMALS AND HUMAN INFANTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/511, 1995.
Description:
A scientific evaluation was made of functional aspects of developmental toxicity of polychlorinated biphenyls (PCBs)-dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in experimental animals and in human infants. ersistent neurobehavioral, reproductive, and endocrine alterations were observed in experimental animals, following in utero an lactational exposure to PCBs, PCDDs, and dPCDFs. he lowest observable adverse effect levels (LOAELs) for developmental neurobehavioral and reproduction endpoints, based on body burdens of TCDD-toxic equivalents (TEQs) in animals, are within the range of current background human body burdens. elatively subtle adverse effects on neurobehavioral development and thyroid hormone alterations have also been observed in infants and children exposed to background levels. xclusive use of the TEF approach may underestimate the risk of neurodevelopmental effects. he use of marker congeners and/or bio-assays based on Ah receptor mediated mechanisms are rapid low cost pre-screening alternatives for expensive and time consuming gas chromatographic-mass spectrometer analysis.