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ASSESSMENT OF THE PROPENSITY FOR COVALENT BINDING OF ELECTROPHILES TO BIOLOGICAL SUBSTRATES
Citation:
Carlson, R. ASSESSMENT OF THE PROPENSITY FOR COVALENT BINDING OF ELECTROPHILES TO BIOLOGICAL SUBSTRATES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/251 (NTIS PB91144949), 1990.
Description:
Electrophilic character is associated with the ability of external agents to interact with centers of electron density in biological macromolecules and to cause the interruption or alternation of normal activity. ith the observation of site specificity in mutagenic events, Pearson's hard/soft acid-based (HSAB) theory is presented as a useful concept in correlating chemical observations in the absence of detailed direct knowledge of the process. ethods for the evaluation of carbon electrophiles (e.g., carbocation character) as reactants are reviewed as potential physical parameters that could be applied in developing quantitative structure-activity relationships.
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ASSESSMENT OF THE PROPENSITY FOR COVALENT BINDING OF ELECTROPHILES TO BIOLOGICAL SUBSTRATES