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EFFECT OF GAVAGE VEHICLE ON HEPATOTOXICITY OF CARBON TETRACHLORIDE IN CD-1 MICE: CORN OIL VERSUS TWEEN-60 AQUEOUS EMULSION (JOURNAL VERSION)
Citation:
Condie, L., R. Laurie, T. Mills, M. Robinson, AND J. Bercz. EFFECT OF GAVAGE VEHICLE ON HEPATOTOXICITY OF CARBON TETRACHLORIDE IN CD-1 MICE: CORN OIL VERSUS TWEEN-60 AQUEOUS EMULSION (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-86/475 (NTIS PB89106884), 1986.
Description:
The investigation was conducted to evaluate the effect of corn oil gavage on the subchronic hepatotoxicity of carbon tetrachloride (CCl(4)). Male and female CD-1 mice were gavaged with 0, 1.2, 12, and 120 mg/kg CCl(4) in either corn oil or 1% Tween-60 vehicles once daily for five consecutive days per week for 90 days. The study revealed that the hepatotoxicity was greater in the corn oil vehicle groups of mice than in the Tween-60 groups. Increases in serum enzyme activities were detected in the 12 mg/kg CCl(4) corn oil male and female groups but not in the corresponding Tween-60 groups. The experimental findings indicate that the corn oil vehicle lowered the no-observed-adverse-level (NOAEL) from CCl(4) exposure by an order of magnitude (from 12 mg/kg to 1.2 mg/kg) and also enhanced the hepatoxicity of CCl(4) in the high dose treatment groups. (Copyright (c) 1986 by the Society of Toxicology.)