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APPLICATION OF PHARMACOKINETIC MODELS TO PREDICT TARGET DOSE
Citation:
Blancato, J. AND K. Bischoff. APPLICATION OF PHARMACOKINETIC MODELS TO PREDICT TARGET DOSE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-94/134 (NTIS PB94190345), 1994.
Description:
The number of new and old chemical compounds to which the human race is exposed has quickly become astronomical. ethods of risk assessment have been slow to develop. n the case of non-therapeutic chemicals, the need for such assessment was not obvious for many years. n the case of therapeutic drugs, the only true means was to simply perform numerous trial and error studies with the patient being one of the experimental instruments. nimal studies are time consuming and often very expensive. ndustry, government and academia have had to scrupulously examine the benefits-to-cost ratio of these studies. he limiting factors appear to be the questions of extrapolation and the compatibility of different metabolic processes in different species. his chapter discusses (1) pharmacokinetics, (2) model development, (3) flow-limited assumptions, (4) membrane-limited assumption, (5) micropharmacokinetic physiologic models and their implementation.
