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ESTIMATION OF MUTAGENIC/CARCINOGENIC POTENTIAL OF ENVIRONMENTAL CONTAMINANTS BY ION-MOLECULE REACTIONS AND TANDEM MASS SPECTROMETRY
Citation:
Freeman, J., J. Johnson, M. Hail, R. Yost, AND D. Kuehl. ESTIMATION OF MUTAGENIC/CARCINOGENIC POTENTIAL OF ENVIRONMENTAL CONTAMINANTS BY ION-MOLECULE REACTIONS AND TANDEM MASS SPECTROMETRY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/028 (NTIS PB90217704), 1990.
Description:
The ability to produce and detect products of model DNA/carcinogen ion-molecule reactions is demonstrated in the ion source and the collision cell of a triple quadrupole tandem mass spectrometer. eaction between adenine and benzoyl chloride in the ion source is shown to produce the DNA adduct benzoyl adenine. he daughter ion mass spectrum of the reaction product is compared to that of the synthesized standard. ass chromatograms of the reaction between mass-selected pyridine ions and various analytes eluting from a GC column into the collision cell are demonstrated and illustrate the ability to detect only the GC eluates that react with pyridine. his technique could provide a rapid and sensitive method for screening complex environmental samples for carcinogens, as well as for estimating the relative mutagenic/carcinogenic potential of environmental contaminants.
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ESTIMATION OF MUTAGENIC/CARCINOGENIC POTENTIAL OF ENVIRONMENTAL CONTAMINANTS BY ION-MOLECULE REACTIONS AND TANDEM MASS SPECTROMETRY