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INFLUENCE OF OZONE ON PENTOBARBITAL PHARMACOKINETICS IN MICE
Citation:
Graham, J., D. Menzel, M. Mole, F. Miller, AND D. Gardner. INFLUENCE OF OZONE ON PENTOBARBITAL PHARMACOKINETICS IN MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-85/451 (NTIS PB87116430), 1985.
Description:
It had been shown that 3 to 5 hr exposures to ambient concentrations of ozone (O3) increase pentobarbital-induced sleeping time in female mice, hamsters, and rats without decreasing heptatic cytochrome P-450 levels or selected mixed function oxidases. To elucidate potential mechanisms involved, clearance of pentobarbital from the blood of O3-exposed mice was examined. Pentobarbital clearance followed first-order kinetics with a one-compartment model. Mice exposed to 1960 micrograms per cu. m. (1ppm) for 5 hr had a 71% increase in the plasma half-life of pentobarbital. It therefore appears possible that pentobarbital-induced sleeping time is increased due to a decrease in hepatic metabolism of pentobarbital.