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COMBINED EFFECTS OF SOLVENTS ON THE RAT'S AUDITORY SYSTEM: STYRENE AND TRICHLOROETHYLENE
Citation:
Rebert, C., W. Boyes, G. Pryor, D. Svensgaard, K. Kassay, G. Gordon, AND N. Shinksy. COMBINED EFFECTS OF SOLVENTS ON THE RAT'S AUDITORY SYSTEM: STYRENE AND TRICHLOROETHYLENE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/339 (NTIS PB93229573), 1993.
Description:
Because exposures to toxic agents typically involve more than one substance, it is necessary to know if combined exposures pose different risks than those to single agents. any solvents have been implicated in central nervous disorders and some of them are known to produce hearing loss, probably mediated by damage to cochlear hair cells. earing loss was studied by recording the brainstem auditory evoked response (BAER) in male Long Evans rats exposed 8 h/day for 5 days to mixtures of styrene (STY) and trichloroethylene (TCE). ose groups included air or solvent apirs (STY/TCE) in the following concentrations (ppm): (0:3000), (250:2250), (500:1500), (750:750) and (1000:0). ecreased BAER amplitude, indicative of hearing loss, was correlated with blood levels of total solvent. he effects were as predicted by a linear dose-addition model, indicating neither synergistic nor antagonistic interactions at the concentrations studied.