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PULMONARY RESPONSE OF WHITE AND BLACK MEN AND WOMEN TO SIX CONCENTRATIONS OF OZONE
Citation:
Seal, Jr., E., W. McDonnell, D. House, S. Salaam, P. DeWitt, S. Butler, J. Green, AND L. Raggio. PULMONARY RESPONSE OF WHITE AND BLACK MEN AND WOMEN TO SIX CONCENTRATIONS OF OZONE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/355 (NTIS PB93228815), 1993.
Description:
Many early studies of respiratory responsiveness to ozone (O3) were done on healthy young white males. he purpose of this study was to determine if any gender or race difference in O3 response exist among white and black, males and females; and to develop concentration-response curves for each of the gender-race groups. hree hundred seventy two subjects (n 90 in each gender-race group), ages 18-35 yr were exposed once for 2.33 h to either purified air, 0.12, 0.18, 0.24, 0.30, or 0.40 ppm O3. Each exposure was preceded by baseline pulmonary function tests (PFTS) and a symptom questionnaire. he first 2h of exposure included alternating 15 min periods of rest and exercise on a motorized treadmill producing a minute ventilation of 25 1 x min -1 x m-2 body surface areas (BSA). fter exposure, subjects completed asset of PFTs-and a symptom questionnaire. Lung function and symptom responses were expressed as percent change from baseline and analyzed using a nonparametric two factor analysis of variance. hree primary variables were analyzed: EV1, SRaw, and cough. tatistical analysis demonstrated no significant differences in response to O3 among the individual gender-race groups. or the group as a whole, changes n the variables FEV1, SRaw, and cough were first noted at 0.12, 0.18, and 0.18 ppm O., respectively. djusted for exercise differences, concentration-response curves for-FEV1 and cough for white males were consistent with previous reports.