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CLASTOGENICITY EVALUATION OF SEVEN CHEMICALS COMMONLY FOUND AT UNCONTROLLED INDUSTRIAL WASTE SITES
Citation:
Sandhu, S., T. Ma, Y. Peng, AND X. Zhou. CLASTOGENICITY EVALUATION OF SEVEN CHEMICALS COMMONLY FOUND AT UNCONTROLLED INDUSTRIAL WASTE SITES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/335 (NTIS PB90199456), 1990.
Description:
Seven chemicals commonly found at industrial waste sites were tested with the Tradescantia-micronucleus (Trad-MCN) assay to evaluate their clastogenic potential. They were: Aldrin, arsenic trioxide, l,2 benz(a,h)anthracene, dieldrin, heptachlor, lead tetraacetate, and tetrachloroethylene. Results of repeated tests for clastogenicity yielded the minimum effective dose (MED) of 0.44 ppm for lead tetraacetate, 3.81 ppm for dieldrin, and 1.88 ppm for heptachlor. rsenic trioxide and 1,2 benz(a,h)anthracene yielded positive responses at the MED of 3.96 ppm and 2.28 ppm, respectively. ldrin and tetrachloroethylene were considered to be immiscible with water, and the test yielded negative responses. esults of tetaachloroethylene fume treatment yielded a positive response at the MED of 30 ppm/min in 2-hr exposures. Five chemicals determined to be clastogens by this test were ranked according to their MED in the descending order of potency as follows: Lead tetraacetate, heptachlor, l,2-benz(a,h)anthracene, dieldrin, and arsenic trioxide. esults of this study indicate that Trad-MCN bioassay could be effectively utilized for assessing the genetic hazard from the leachates and volatile compounds emanating from uncontrolled industrial waste sites.