Citation:

Betowski, L. AND T.L. Jones. APPLICATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY TO ENVIRONMENTAL ANALYSIS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/4-89/033 (NTIS PB90116963), 1989.

Description:

High performance liquid chromatography (HPLC) coupled with nass spectronetry (MS) is described for the analysis of samples for environmental pollutants. uring the course of this work different techniques were used to increase both the sensitivity and specificity of HPLC/MS. hese included the utilization of two different interfaces for the mass spectrometer - the thermospray and the particle beam systems. Refinements to the thermo spray system were made with the use of a wire-repeller to enhance sensitivity and also to increase the structural information obtained from mass spectra. he operation of the instrument in the discharge negative ionization mode further increased the specificity of these techniques as did the use of a triple quadrupole mass spectrometer in the HPLC/MS system. Two different sets of compounds were used in this study. rganic dyes were used to test the improvements in the system. ince work was performed with dyes previously and since dye compounds encompass a variety of structural functionalities, the dyes made good test compounds. hlorinated herbicides were studied in an effort to analyze for these compounds directly without having to prepare derivatives before separation. his report covers a period from October 1, 1908, to May 31, 1909, and work was completed as of July 31, 1989.

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