You are here:
UPTAKE, METABOLISM, AND ELIMINATION OF 14C-LABELED 1,2,4-TRICHLOROBENZENE IN RAINBOW TROUT AND CARP
Citation:
Melancon, M. AND J. Lech. UPTAKE, METABOLISM, AND ELIMINATION OF 14C-LABELED 1,2,4-TRICHLOROBENZENE IN RAINBOW TROUT AND CARP. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-80/433 (NTIS PB84110667), 1980.
Description:
Fingerling rainbow trout (Salmo gairdneri) were exposed to 14C-labeled 1,2,4-trichlorobenzene (TCB) for 8 h in a static exposure (0.018 mg/1) or for 35 d in a continuous-flow exposure (0.020 mg/1) followed by a subsequent elimination period. For the 2 d after the 8-h exposure, the half-time (t1/2) of elimination of 14C from muscle and liver was 0.4 d, while after the 35-d exposure an early rapid elimination of 14C from these tissues (t1/2 = 0.4 d) was followed by a slower elimination (t1/2 = 50 d) during d 4-36. The maximum bioconcentration factors for 14C in muscle and liver were 51 and 102 after the 8-h exposure and 89 and 389 during the 35-d exposure. The values for bile were much greater, reaching 240 after the 8-h exposure and 1400 during the 35-d exposure. When larger trout and carp (Cyrpinus carpio) were exposed to (14C)TCB (0.2-0.4 mg/1) the bioconcentration factor for bile 14C to water 14C was less than 100.