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EFFECTS OF MANGANESE AND THEIR MODIFICATION BY HEXAMETAPHOSPHATE
Citation:
Bull, R. EFFECTS OF MANGANESE AND THEIR MODIFICATION BY HEXAMETAPHOSPHATE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-77/024 (NTIS PB272264), 1977.
Description:
The ability of oral Mn(+2) to produce the depletions of dopamine in the corpus striata characteristic of the Parkinson-like syndrome in manganese workers was examined in rats. A second objective of this work was to study the biological interactions between Mn(+2) and sodium hexametaphosphate ((NaPO3)6) administered simultaneously in drinking water. The authors conclude that Mn(+2) in drinking water presents little hazard in terms of central nervous system involvement in a homogeneous population. The involvement of genetic factors which have been suggested to account for the sporadic occurrence of Parkinson-like symptoms in Mn(+2) workers can not be excluded. The use of (NaPO3)6 for Mn(+2) complexation as an alternative to removal in drinking water treatment appears safe from a health standpoint if carefully controlled to avoid excessive amounts of (NaPO3)6.