You are here:
CARBOXYHEMOGLOBIN FORMATION DUE TO CARBON MONOXIDE IN RATS
Citation:
Benignus, V. AND Z. Annau. CARBOXYHEMOGLOBIN FORMATION DUE TO CARBON MONOXIDE IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/549 (NTIS PB95148102), 1994.
Description:
The Coburn-Forster-Kane equation (CFKE) ia a well tested model for prediction of COHb formation due to carbon monoxide (CO) exposure in humans. here have been few and relatively poorly tested attempts to implement a CFKE for rats. uch an implementation is of interest because many experiments on the effects of CO in rats were done without measuring COHB. o extrapolate from rats to humans requires a rat version of the CFKE.Rats were exposed to 150, 250, 500 and 1000 ppm CO for up to 240 min. Blood gases and COHb were measured. FKE was implemented for rats by using parameters found in the literature and estimating them from the data. t was deduced from the blood-gas data that rats hyperventilate slightly as COHb increases. he blood-gas data were used to estimate ventilation and alveolar capillary oxygen partial pressure. he hyperventilation required an iterative solution to the CFKE. he iterative CFKE predictions were found to differ statistically from observations, but in explainable ways and/or in small amounts.