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INTERNATIONAL TOXICITY EQUIVALENCY FACTOR (I-TEF) METHOD OF RISK ASSESSMENT FOR COMPLEX MIXTURES OF DIOXINS AND RELATED COMPOUNDS
Citation:
Barnes, D., F. Kutz, D. Bottimore, H. Greim, D. Grant, AND J. Wilson. INTERNATIONAL TOXICITY EQUIVALENCY FACTOR (I-TEF) METHOD OF RISK ASSESSMENT FOR COMPLEX MIXTURES OF DIOXINS AND RELATED COMPOUNDS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/6-90/009 (NTIS PB91125625), 1990.
Description:
The International Toxicity Equivalency Factor (I-TEF) Method of Risk Assessment for Complex Mixtures of Dioxins and Related Compounds is a revised interim procedure for estimating the risks considered with exposures to mixtures of dioxins and furons such as incinerator fly ash, contaminated soil, and biological media. his updated method was developed by the Pilot Study on International Information Exchange on Dioxins and Related Compounds and has been adopted by the eight nation group as the preferred interim method. he I-TEF scheme should facilitate the exchange of information concerning the toxicological significance of contaminated samples between scientists and regulatory agencies worldwide. he method is based on the most recent toxicological data from a variety of biological responses including carcinogenicity, terctogenicity, immunotoxicity, lethality and etymotic induction. he report describes the major differences in the new scheme compared to the numerous existing TEF schemes.