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SISTER CHROMATID EXCHANGE AND GENOTOXICITY MEASUREMENTS USING POLYCHAETE WORMS
Citation:
Pesch, G. SISTER CHROMATID EXCHANGE AND GENOTOXICITY MEASUREMENTS USING POLYCHAETE WORMS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/013 (NTIS PB90217647), 1990.
Description:
Contaminants entering coastal marine environments may affect the genetic constitution of exposed organisms by causing shifts in gene pool composition through selective pressures or by acting directly on the genetic material to cause damage. he latter problem is referred to as genotoxicity. his article reviews genotoxicity studies done with marine polychaetes, with special emphasis on the chromosomal response of sister chromatid exchange (SCE). Chromosomal responses have been studied in the polychaete Neanthes arenaceodentata exposed to pure compunds and radiation, and in the polychaete Nephtys incisa exposed to a complex mixture. ll of the published results to date have come from two laboratories, the U.S. National Laboratory at Livermore, California (Harrison and co-workers) and a U.S. EPA Laboratory at Narragansett, RI (Pesch and co-workers). his article reviews and summmarizes the work in the context of assessing risks associated with mutagens and carcinogens in marine environments.