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MYELIN BASIC PROTEIN-MRNA USED TO MONITOR TRIMETHYLTIN TOXIC NEUROPATHY IN RATS
Citation:
Veronesi, B., J. Pringle, AND C. Mezei. MYELIN BASIC PROTEIN-MRNA USED TO MONITOR TRIMETHYLTIN TOXIC NEUROPATHY IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/159 (NTIS PB91231274), 1991.
Description:
Trimethyltin (TMT) is an alkyltin that selectively targets neurons of the limbic system. ene probe (i.e., mRNA) for myelin basic protein (MBP) was used to monitor this toxic neuropathy. prague Dawley rats, were dosed (IP) acutely with hydroxide at neuropathic (8.0 mg/kg) or non-neuropathic (0.8 mg/kg) doses, and sampled at 1,3, and 7d postexposure of correlate progression of hippocampal neuropathology with changes in levels of the probe (i.e., MBP-mRNA). n the absence of overt histological damage, depressions of 17, 36 and 46%, 25 and 29% levels occurred in the anterior brain at 1,3, and 7d respectively. n the posterior brain depression of 23% and 26% occurred in mRNA at 3d and 7d postexposure, 26% at 7d. hese data demonstrate that molecular endpoints can be used to monitor toxic neuropathies and further establish their relative sensitivity over conventional neuropathic endpoints to monitor the pathogenesis of a toxic neuropathy.