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INHALATION TOXICOLOGY OF AIRBORNE PARTICULATE MANGANESE IN RHESUS MONKEYS
Citation:
Coulston, F. AND T. Griffin. INHALATION TOXICOLOGY OF AIRBORNE PARTICULATE MANGANESE IN RHESUS MONKEYS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-77/026 (NTIS PB268643), 1977.
Description:
Four male and four female rhesus monkeys were exposed to manganese oxide (Mn3O4) aerosol at 100 micrograms/cubic meter in an exposure chamber for periods up to 66 weeks. Three male and three female monkeys were maintained as unexposed controls. Observation and clinical chemistry during the experiment showed minor changes in excretion, and no evidence of toxic effects. Manganese tissue levels showed small increases except in lung (five-fold) and pons (four-fold). No macro- or microscopic pathology was observed. Two rhesus monkeys were exposed to 5 mg/cubic meter of the same material for 23 weeks, and observed for 10 months thereafter. Large increases in excretion of manganese were observed in both urine and feces, but no evidence of neurologic or other toxicity was seen. Two groups of 4 and of 14 rats were exposed in the same manner to 100 micrograms/cubic meters of the same compound for 8 weeks. These experiments were done to examine changes in excretion and tissue levels during and after exposure.