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NEONATAL TRIETHYLTIN EXPOSURE ALTERS ADULT ELECTROPHYSIOLOGY IN RATS
Citation:
Dyer, R., W. Howell, AND Lawrence W. Reiter. NEONATAL TRIETHYLTIN EXPOSURE ALTERS ADULT ELECTROPHYSIOLOGY IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/163 (NTIS PB83189589), 1981.
Description:
In adults, triethyltin (TET) produces degeneration of white mater, edema, vacuolization of myelin and histoxic hypoxia. To determine the functional consequences of perinatal exposure to TET, albino rats were administered either 0,3,6, or 9 mg/kg TET on postnatal day 5. Upon reaching adulthood, the rats were implanted with electrodes for recording visual evoked potentials (VEPs) and hippocampal afterdischarges (ADs). In addition to these tests, 17 days of kindling trials were administered to the rats followed by testing with pentylenetetrazol and picrotoxin for seizure susceptibility.