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EFFECT OF RESIDUAL SPLENIC FUNCTION AND FOLATE LEVELS ON THE FREQUENCY OF MICRONUCLEATED RED BLOOD CELLS IN SPLENECTOMIZED HUMANS
Citation:
Schreinemachers, D. AND R. Everson. EFFECT OF RESIDUAL SPLENIC FUNCTION AND FOLATE LEVELS ON THE FREQUENCY OF MICRONUCLEATED RED BLOOD CELLS IN SPLENECTOMIZED HUMANS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/140 (NTIS PB91218982).
Description:
Rates of micronucleated erythrocytes in the peripheral blood of splenectomized individuals can be used as an index of genetic damage to erythrocyte recursor cells in the bone marrow. his is in contrast to non-splenectomized humans, whose micronucleated erythrocytes are removed by the spleen. any subjects whose spleen has been removed surgically have residual spleen tissue and consequent residual spleen function (RSF), which can be measured by the percentage of "pitted" peripheral red blood cells. n this study evidence of RSF was associated with decreased rates of micronucleated erythrocytes. nalysis of data limited to subjects with minimal spleen function suggested an inverse association between the incidence of micronucleated erythrocytes and serum folate levels that was not apparent in the absence of stringent control for RSF.