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RELATIONSHIP BETWEEN THE METABOLISM OF HALOACETONITRILES AND CHLOROFORM AND THEIR CARCINOGENIC ACTIVITY
Citation:
Pereira, M., F. Daniel, AND E. Lin. RELATIONSHIP BETWEEN THE METABOLISM OF HALOACETONITRILES AND CHLOROFORM AND THEIR CARCINOGENIC ACTIVITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-84/203 (NTIS PB84246230).
Description:
Halogenated acetonitriles, found in chlorinated drinking water, are formed by the reaction of chlorine with algae, fulvic acid, and proteinaceous material in the source water. The metabolism of halogenated acetonitriles was investigated in relation to their possible carcinogenic activity. Chloroacetonitrile (CAN), dibromoacetonitrile (DBAN), dichloroacetonitrile (DCAN), bromochloroacetonitrile (BCAN), and trichloroacetonitrile (TCAN) were shown to bind the nucleophilic trapping agent, p-nitrobenzylpyridine, without metabolic activation and to produce strand breaks in the DNA of cultured human CCRF-CEM cells. In addition, DCAN bound DNA in vitro without metabolic activation producing an adduct to adenine, and DBAN bound rat-liver DNA following oral administration.