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CHLOROFORM INDUCED MULTIPLE FORMS OF ORNITHINE DECARBOXYLASE: DIFFERENTIAL SENSITIVITY OF FORMS TO ENHANCEMENT BY DIETHYL MALEATE AND INHIBITION BY ODC-ANTIZYME
Citation:
Savage, Jr., R., K. Nofzinger, C. Bedell, A.B. DeAngelo, AND M. Pereira. CHLOROFORM INDUCED MULTIPLE FORMS OF ORNITHINE DECARBOXYLASE: DIFFERENTIAL SENSITIVITY OF FORMS TO ENHANCEMENT BY DIETHYL MALEATE AND INHIBITION BY ODC-ANTIZYME. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/057 (NTIS PB90103474).
Description:
We have previously reported that chloroform induces rat liver ornithine decarboxylase (ODC). In both male and female rat liver this induction is dose-dependent and maximal 18 h after a single intraperitoneal dose (Savage et al., 1982). To distinct forms of the enzyme are induced in rat liver (Pereira et al., 1983). Pretreatment of animals with diethyl maleate enhances the effect of chloroform (Savage et al., 1987). In addition, chloroform induces hepatic ornithine decarboxvlaseantizyme (0DC-AZ) in rat liver (Savage et al., 1988). In this study, we report the effect of diethyl maleate pretreatment on the chIoroiorm induction of two different forms of male rat liver ODC and the sensitivity of the two forms of the enzyme to inhibition by ODC-AZ.
