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COMPARATIVE TOXICITY OF AZINPHOS-METHYL TO HOUSE MICE, LABORATORY MICE, DEER MICE, AND GRAY-TAILED VOLES
Citation:
Meyers, S. AND J. Wolff. COMPARATIVE TOXICITY OF AZINPHOS-METHYL TO HOUSE MICE, LABORATORY MICE, DEER MICE, AND GRAY-TAILED VOLES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/272.
Description:
The authors conducted a laboratory toxicity study on house mice and laboratory mice, gray-tailed voles, and deer mice as part of a comprehensive laboratory and field study to field-validate laboratory-based risk assessment of agrichemicals. he single dose oral LD50 for the organophosphorus insecticide azinphosmethyl was 10, 11, 32, 48 mg/kg body mass in wild house mice, laboratory mice, gray-tailed voles, and deer mice, respectively. en-day dietary LC50's were 277 ppm for laboratory mice, 297 ppm for gray-tailed voles, and 1180 ppm for deer mice. reated animals lost more mass, consumed less food, and had depressed cholinesterase (ChE) activity compared to controls. ive-day LC50's were significantly higher than 10-d LC50's for laboratory mice and deer mice. or all three species, animals that died during dietary LC50 tests had mean (ChE) activity of 50 to 55% of controls compared to 56 to 70% for those animals that did not die. e conclude that (1) laboratory mice were not representative of deer mice or gray-tailed voles with respect to sensitivity to the pesticide, but provided a conservative estimate for risk assessment; (2) 5-d dietary LC50 tests provide substantially higher estimates of toxicity to rodents than do 10-d test, and (3) ChE depression of 45 to 50% was lethal.