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INTERACTION BETWEEN GAMMA-HEXACHLOROCYCLOHEXANE AND THE GASTROINTESTINAL MICROFLORA AND THEIR EFFECT ON THE ABSORPTION, BIOTRANSFORMATION, AND EXCRETION OF PARATHION BY THE RAT
Citation:
Chadwick, R., M. Copeland, R. Froehlich, N. Cooke, AND D. Whitehouse. INTERACTION BETWEEN GAMMA-HEXACHLOROCYCLOHEXANE AND THE GASTROINTESTINAL MICROFLORA AND THEIR EFFECT ON THE ABSORPTION, BIOTRANSFORMATION, AND EXCRETION OF PARATHION BY THE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/102 (NTIS PB84246438).
Description:
Pretreatment of rats with the organochlorine insecticide lindane reduced the estimated absorption rate of parathion from the gastrointestinal tract. Lindane pretreatment also significantly reduced the metabolism of parathion to p-nitrophenol in vivo. Lindane pretreatment altered the gastrointestinal (GI) microflora by increasing the ratio of anaerobes to aerobes. Consistent with this alteration was a significantly greater retention of unaltered parathion and the microbial metabolite aminoparathion in the GI tract of the lindane-pretreated rats 1 h after the administration of parathion. Enhanced conversion of parathion to aminoparathion together with a slower absorption rate may play a role in the antagonism parathion toxicity by lindane.